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亿万富豪和超模的 “逆龄密码”:端粒如何重塑生命长度 KellyOnTech

亿万富翁比如 Jeff Bezos、Sam Altman、Peter Thiel 与超模 Veronica Webb、Kate Moss 等等之间,究竟藏着怎样意想不到的交集?

他们都将目光投向了抗衰老与长寿领域的研究,纷纷投资相关公司。而超模们也对端粒修复产品情有独钟,近乎痴迷。2025年乙巳蛇年已至,在这个万象更新的年度里,我们一起解锁端粒的奥秘。

为什么说理论上讲人可以活到120岁?

端粒(Telomere)是染色体末端的保护帽,帮助细胞保持健康,由重复的 DNA 序列和相关蛋白组成。

为了更直观地理解,不妨想象一下鞋带。端粒就像鞋带末端的塑料套,看似毫不起眼,却默默守护着鞋带的完整性,保护我们的 DNA 不受损坏或纠缠。细胞每一次分裂,就如同鞋带在日常使用中不断受到摩擦,端粒也会随之逐渐变短,恰似塑料套慢慢磨损。当塑料套被磨没了,鞋带就会从末端散开,直到没法用了。同理,随着时间的推移,当端粒变得太短时,细胞就无法正常工作。端粒与衰老和某些疾病的产生有着千丝万缕的联系。

端粒示意图

当我们出生的时候,在每个干细胞里,大约有5000-6000个端粒,而科学家测算过,端粒从开始磨损直至耗尽的时间大约为 120 年。这一科学发现,也正是 “人理论上可以活到 120 岁” 这一说法的重要计算依据。

如何延缓端粒的衰退?

如何有效延缓端粒衰退,成为了科学界与追求健康长寿人群密切关注的焦点。

端粒长度,作为衡量衰老进程与细胞健康状况的关键生物标志物,其重要性不言而喻。研究表明,端粒越短,机体与衰老相关疾病的距离就越近,同时,长期压力以及不良生活方式,像不合理饮食、运动量匮乏等,也都与端粒缩短有着千丝万缕的联系。

虽然端粒会随着时间的推移逐渐变短,最终导致细胞衰老和死亡,但是某些细胞(如干细胞和癌细胞)可以借助一种名为端粒酶(Telomerase)的酶来延长端粒长度,维持细胞的持续分裂能力,从而延缓衰老进程。

市面上有延长端粒长度来抗衰老的产品吗?

在追求青春永驻、对抗衰老的漫漫长路上,无数人都在翘首以盼,市面上究竟有没有能够通过延长端粒长度来实现抗衰老的神奇产品呢?

截至目前,这类旨在延长端粒长度以达到抗衰目的的产品,依旧处于紧锣密鼓的试验阶段。不过,一款名为 Telomir-1 的产品,已在业界成功吸引了众多目光,成为众人瞩目的焦点。它是由专注于抗衰老科学研究,并在纳斯达克上市的制药公司 Telomir Pharmaceuticals, Inc. 精心研发的新型小分子,其核心使命便是延长端粒长度。2024 年 11 月,Telomir 公司公布了具有开创性意义的临床前研究结果,这一成果令人振奋不已,不仅证实了 Telomir-1 具备延长生物体寿命的潜力,更惊喜地发现它还能显著改善健康寿命,让生命在更长的时间里保持良好状态。

据该公司介绍,Telomir-1 从最初的小鼠试验,到后续在狗身上展开的深入研究,再到如今的人体细胞试验,一路表现出色,成果斐然。在实验数据中,它能够将人体干细胞里的端粒含量提升 10 倍之多。以年老的狗为例,原本其干细胞中仅有 300 个端粒,经过 Telomir-1 的作用后,端粒数量飙升至 3000 个,从外观上看,狗的面貌焕然一新,姿态也变得更加矫健,全身仿佛重新焕发了生机,活力满满。

尽管目前这项技术还处于临床试验阶段,尚未完全成熟,但它无疑为人类在抗衰老领域的探索,点燃了一盏全新的希望之灯。遥想古今中外,上至帝王将相,下至普通百姓,无不对返老还童的美好愿景充满向往,或许在不久的将来,这一曾经只存在于幻想中的场景,真的会成为现实,让我们共同满怀期待,拭目以待。

值得特别强调的是,Telomir-1 这款神奇的药物,其应用价值远不止于抗衰老。它还在医疗领域展现出了巨大的潜力,有望用于治疗早衰症、2 型糖尿病,以及一系列与衰老密切相关的疾病,如阿尔茨海默病、某些类型的癌症、威尔逊病和骨关节炎等。这意味着,它不仅可能改写人类对抗衰老的历史,还将为众多患者带来战胜疾病的曙光,助力医学发展迈向新的里程碑。

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Understand the Core of the AI Era—Or Get Left Behind!

What Defines the AI Era?

Is it data? Algorithms? Computing power? While these elements are essential, they are not the true core of the AI era. The real game-changer is decision quality.

AI has transitioned from the lab to the real world not just because it can process vast amounts of data or execute complex calculations, but because it has fundamentally improved the way decisions are made. This leap in decision-making capability is what’s reshaping industries, transforming our daily lives, and defining the future of technology.


Go Battle: The Pinnacle of AI Decision-Making

Remember the Go* match that shocked the world in 2016? AlphaGo played against the top human player Lee Sedol. Since then, no human has ever defeated AI in the world of Go. AlphaGo’s victory is not accidental. Every move it made was a carefully calculated decision. Unlike human players, who rely on intuition, experience, and real-time judgment, AI evaluates countless possibilities, predicting dozens — or even hundreds — of moves ahead. This duel was more than the victory or defeat of a Go game; it marked a revolution in decision-making itself.

*Go, an ancient Chinese strategy game is played with black and white stones, where the player who controls the most territory wins. Known as the “King of Board Games,” it embodies art, wisdom, and deep philosophy.

Autonomous Driving: AI Decision-Making in the Real World

The improvement in the quality of AI decision-making is not only reflected on the chessboard but also in our daily lives. Autonomous driving is one of the best examples.

What is the core of autonomous driving? It is the perfect fusion of perception and decision-making.

The limitations of human driving: Humans rely on our eyes to navigate the road, but our field of vision is limited and blind spots are unavoidable. We use our ears to detect sounds, yet distractions — music, conversations, or outside noise — often distract us. More critically, human learning is finite. Once we learn to drive, few of us refine our driving skills further. Fatigue, stress, and emotions like road rage further increase accident risks.

Advantages of AI driving: In contrast, AI-driven cars are equipped with multiple cameras, radars and sensors that provide a 360-degree view of the surrounding environment without blind spots. AI doesn’t get distracted, fatigued, or emotional. Unlike humans, it learns and optimizes continuously, adapting to complex road conditions, and improving safety over time. Eventually, AI-driven cars will surpass human drivers in reliability and efficiency.

From the strategic brilliance of Go to the precision of autonomous vehicles, AI is changing the way the world works with more efficient and accurate decisions. AI is transforming decision-making across every domain. As AI systems become more advanced, making faster and more accurate choices than ever before, they are redefining how the world operates. 

As AI decision-making seeps into every corner of life, the real question is: How can we find our place in this wave? In this AI-driven revolution, are you ready?

Special Notes

Over the past 20 years, I have had the privilege of working with founders, investors, and technical teams from technology companies worldwide, particularly in China, the United States, Canada, Singapore, the United Kingdom, the Netherlands, Germany, Japan, and beyond. Given the diverse national and cultural backgrounds, misunderstandings are sometimes inevitable, especially when it comes to perceptions of China.

To bridge this gap, starting this year, I have decided to regularly share insights from thought leaders in China’s tech industry, offering cutting-edge perspectives and unique viewpoints.

My aim is to foster deeper mutual understanding and break down unnecessary barriers. After all, in an era of rapid AI advancements, humanity must work together to navigate the complexities of intelligent technologies and jointly build a brighter future.

Liang Ning Introduction

The above content is compiled based on Liang Ning’s understanding of the AI era.

Liang Ning is an outstanding business thinker in China’s technology field. In her 20s, she worked with Academician Ni Guangnan to develop China’s domestic chips and operating systems. Later, she founded a well-known outdoor travel portal, Green Man. After the website was acquired by Tencent, she served as Tencent’s product manager. After leaving in 2014, she focused on in-depth research of enterprises.

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No Touch Love: Exploring The Enduring Influence of AI empowerment on humanity

Recently, the global media has been flooded with talk of the threat of artificial intelligence. A Google search for “AI threats” turned up more than 270 million related contents in 34 seconds.

American economist Robert Solow once said, “People always overestimate the short-term benefits brought by a technology but underestimate its long-term impact.” Here I use a story “No Touch Love” to discuss about the long-term impact of AI empowerment on humanity.

Story: No Touch Love

The story takes place in 2042, in the post-coronavirus era, people have to learn coexist with viruses. Chinese “fist-holding salute “has become an internationally popular etiquette because it does not require physical contact.

Chinese “fist-holding salute” 

In that era, many people barely left their homes, and all their daily living could be met by unmanned express delivery and household robots. Some people no longer pursue full-time jobs but live a satisfying life by accepting part-time jobs such as designing skins and props for VR games. For example, the heroine in the story — Chen Nan.

Chen Nan, who is based in Singapore, witnessed the death of her grandfather, grandmother and both parents during the outbreak of the coronavirus pandemic, which caused mental trauma and suffered from a phobia that isolated herself from the world.

Despite this, Chen Nan still longs to be loved. She fell in love with a young man from Brazil, Garcia, online, a kind of contactless spiritual love. Whenever Garcia asked to meet offline, Chen Nan refused again and again because she was extremely afraid of being intimate with her lover.

To help his loved one to overcome her fears and prove that even huge culture differences cannot stop the love between them, Garcia even registered a virtual avatar that replicates 100% of his own image, down to his poles and scars. He put his AI-powered avatar into a Singaporean city simulator and lives his life like an ordinary Singaporean. He was proficient in using various local applications and complying with local regulations and guidelines. However, when he again requested to meet Chen Nan offline, he was still rejected.

AI 2041

The story ends here. If you are interested in how Garcia uses various AI applications to win Chen Nan, you can read the book “AI 2041”co-authored by Kai-Fu Lee and Chen Qiufan.

Kai-Fu Lee is the founder of Innovation Factory, which Time magazine listed him as one of the 100 most influential people in artificial intelligence in 2023. Chen Qiufan is a sci-fi author, screenwriter, translator, and curator who was nominated for the second Sanlian Humanities City Award in 2023.

AI Technology that Makes People’s Lives Easier

Bio-Sensitive Film

In the future, we no longer need to always carry a variety of physiological data monitoring instruments. We only need a thin bio-sensing film. This kind of film, which is attached to the inside of the wrist, can display various physiological data in real time (including whether the vaccine in the body is effective), and it is a Digital Health Profile (DHP) certified by the national medical institution.

Digital Medical Records

Birth, old age, sickness and death are inevitable experiences in life. Digital medical records will greatly improve the efficiency of communication between doctors and patients, as well as the effectiveness of disease diagnosis and treatment. In the future, our biochemical data will be collected through various sensors.

For example, bio-sensor film can obtain body temperature, heart rate, bioelectricity, and other parameters. Micro-sensors enter the body in the form of capsules, and can perform blood testing, cell sampling, and monitoring tumor markers, without the need of invasive operations. Even human excrement can be analyzed for its composition through the smart toilets.

In addition, all data will be transmitted to the cloud and reports will be automatically generated by the medical AI, and the transmission process will be encrypted to prevent theft by criminals.

Will Artificial Intelligence Threaten Human Existence

As artificial intelligence becomes more and more powerful, we can’t help but wonder: Will AI pose a threat to human existence?

There are ongoing debates about this in the philosophical community, but it is broadly believed that if AI has self-awareness, then the end of mankind will not be far away. The definition of self-awareness varies. However, it has the following characteristics that are unanimously agreed:

(1)Able to describe the surrounding environment and things through language, and make corresponding evaluations.

(2)The ability to reflect on oneself.

Once artificial intelligence has self-awareness, it means that it can think independently, understand the meta-theorems and meta-rules of things, and is no longer bound by the rules and definitions of the human world.

On the one hand, we are looking forward to the various conveniences brought by the continuous enhancement of AI functions, such as smart homes, smart robots, smart transportation and so on, but on the other hand, we are worried that the singularity of AI with self-awareness is approaching.

When discussing the future of artificial intelligence, although it is full of uncertainties and challenges, we can remain optimistic, face it with an open mind, look at the situation with a smile. There is no need to overthink, and what should come will come naturally.

The original article comes from Mans International website

中文版

《无接触之爱》:AI 赋能对人类的长期影响 KellyOnTech

2024年春节已经结束,我们正式迎来了甲辰龙年,您对这一年有什么期待呢?我们的老祖宗很有智慧,把龙塑造成充满力量和智慧的吉祥物。

最近,全球媒体充斥着有关人工智能威胁的言论。在谷歌搜索“人工智能威胁”,仅仅在34秒钟内就找到了2.7亿多个相关内容。

在谷歌搜索“人工智能威胁”结果显示

美国经济学家罗伯特·索洛(Robert Solow)曾经说过:“人们总是高估一项科技所带来的短期效益,却又低估它的长期影响。” 或许我们可以向老祖宗学习,从积极的角度来看待功能比人类更强大的人工智能。在这里借《无接触之爱》这个故事来展望一下 AI 赋能对人类的长期影响。

《无接触之爱》

故事发生在2042年,后新冠时代,人们不得不学会与病毒共存。中国人的“抱拳礼”由于无需肢体接触,成了一种国际流行的礼仪。

中国人的“抱拳礼” (拱手礼)

在那个时代,许多人几乎足不出户,所有生活需求都能通过无人快递和家务机器人来满足。一些人不再追求全职工作,而是通过接受一些设计VR游戏皮肤和道具等兼职工作来过上自己满意的生活。比如,故事中的女主人公 – 陈楠。

身在新加坡的女主人公陈楠在新冠肺炎疫情爆发期间,亲眼目睹了自己的爷爷、奶奶和双亲离世,而造成了精神创伤,患上了一种把自己与世隔绝的恐惧症。

尽管如此,陈楠心中依然渴望被爱。她和一位来自巴西的小伙子加西亚在线上展开了恋爱,一种无接触式的精神恋爱。每当加西亚提出线下见面的要求时,陈楠一次又一次地拒绝了,因为她极度害怕与恋人亲密接触。

为了帮助心爱之人克服恐惧,证明即使文化差异巨大,也无法阻止他们之间的爱情,加西亚甚至注册了一个虚拟人,100%复制了自己的形象,连毛孔和伤疤都丝毫不差。他将AI驱动的虚拟化身放入新加坡城市模拟器中,以普通新加坡人的方式生活,并熟练使用各种本地应用,遵守当地的法规和准则。然而,当他再次提出与陈楠线下见面的请求时,依然遭到了拒绝。

《AI 未来进行式》

故事就讲到这里啦。如果您对加西亚如何利用各种人工智能应用技术抱得美人归感兴趣,可以阅读由李开复和陈楸帆联合创作的书 《AI 未来进行式》。

图片来源:搜狐网. 《AI未来进行式》书籍封面

李开复是创新工厂的创始人,时代杂志将其列为2023年人工智能领域最具影响力的100人之一。陈楸帆是科幻作家编剧翻译和策展人,他在2023年荣获了第二届三联人文城市奖提名。

让人们生活更加便利的AI 技术

在未来,我们不再需要随时携带各种监测各种生理数据的仪器了,只需要一片薄薄的生物感应贴膜就搞定。这种贴在手腕内侧的贴膜,能够实时显示各种生理数据(包括体内疫苗是否有效),而且是经过国家医疗机构认证的数字健康凭证(Digital Health Profile,DHP)。

图片来源:University of Bath. 生物感应贴膜示意图

生老病死是人生中不可避免的经历。数字化病历将大大提高医生与患者之间的沟通效率,以及疾病诊断和治疗的效果。未来,我们的生化数据将通过各种传感器进行采集。例如,生物感应贴膜可以获取体温、心率、生物电等参数;微型传感器以胶囊形式进入体内,可以进行化验血液、细胞取样、监测肿瘤标志物等工作, 不再需要侵入性的操作。甚至人体的排泄物也可以通过智能马桶分析其成分。另外,所有数据传送至云端后,将由医疗AI自动生成报告,并且传输过程都将进行加密,以防止被犯罪分子盗用。

人工智能会威胁人类的生存吗?

随着人工智能变得越来越强大,我们不禁会思考一个问题:人工智能是否会对人类的生存构成威胁?

目前哲学界对此争论不休,但大致上认为,如果人工智能具备了自我意识,那么人类的末日也就不远了。关于自我意识的定义,说法不一。不但它具有以下特征得到了一致认同:

(1)能够通过语言,描述周遭的环境和事物,并且做出相应的评价;

(2)能够对自身进行反思。

一旦人工智能具备了自我意识,也就意味着它可以自主思考,理解事物的元定理和元规则,不再受人类世界的规则和定义所束缚。

我们一方面期待着人工智能功能的不断增强带来的各种便利,如智能家居、智能机器人、智慧交通等等,但另一方面又担心人工智能具有自我意识的奇点即将到来。

在探讨人工智能的未来时,我们或许可以借鉴白居易的诗 “但见波涛不见人,江湖思绪万端。笑看风生与云起,不思量,自难忘。” 正如诗中所言,尽管未来充满了不确定性和挑战,但我们可以保持乐观,豁达地面对,笑看风云,无需思虑过重,该来的自然会来。

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KellyOnTech Quote Of The Week 2021.12.24 And More

What inspired you this week?

KellyOnTech Quote of the Week 2021.12.24

“Be content with what you have; rejoice in the way things are. When you realize there is nothing lacking, the whole world belongs to you.” Lao Tzu

Latest Videos and Blogs

Video: The entrepreneurial story of Veroniek Vermeulen and the Silatha she founded

Have you made any positive changes this week? We want to hear from you. 

Love yourself, take a good rest, have fun with your loved ones. Tomorrow is another day:)

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Resource page – Mans International Be Your Own Boss program

Welcome to Mans International Be Your Own Boss program

How to join Mans International Be Your Own Boss program?

About Mans International

© Mans International, 2021. No part of www.mansinternational.org may be reproduced in whole or in part in any manner without the permission of Mans International.

KellyOnTech Quote Of The Week 2021.09.24 and More

KellyOnTech-quote-of-the-week-2021.09.24

What inspired you this week?

KellyOnTech quote of the week 2021.09.24

“When everything seems to be against you, remember that the airplane takes off against the wind, not with it.” Henry Ford

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Video: What are the latest developments in chip processing technology?

Blog: What are the latest developments in chip processing technology?

Have you made any positive changes this week? We want to hear from you. 

Love yourself, take a good rest, have fun with your loved ones. Tomorrow is another day:)

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Welcome to Mans International Be Your Own Boss program

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Weekly Update – KellyOnTech Quote Of The Week 2021.09.10 and More

KellyOnTech-quote-of-the-week-2021.09.10

What inspired you this week?

KellyOnTech Quote Of The Week 2021.09.10

“Education is not the learning of facts, but the training of the mind to think.” Albert Einstein

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Video: Next-generation AI-driven 3D eye tracking technology – Eyeware

Blog: Next-generation AI-driven 3D eye tracking technology – Eyeware

Have you made any positive changes this week? We want to hear from you. 

Love yourself, take a good rest, have fun with your loved ones. Tomorrow is another day:)

Back to Home Page

Resource page – Mans International Be Your Own Boss program

Welcome to Mans International Be Your Own Boss program

How to join Mans International Be Your Own Boss program?

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© Mans International, 2021. No part of www.mansinternational.org may be reproduced in whole or in part in any manner without the permission of Mans International.

How would you treat such a student? A true story | Mans International Be Your Own Boss program

How would you treat a student - Mans International be your own boss program

Hello, my name is Kelly. Your guide to being your own boss. Today I will tell you a true story.

There was a junior high school student who was very introverted and did not like to talk in school. He seemed to be unhappy all the time. If you were a physical education teacher, how would you treat him?

One day, the physical education teacher asked the student to go to the playground to participate in the school basketball team selection after class. On the basketball court, this student went on a rampage, desperately trying to get the ball, but it was all in vain and eventually lost. He left silently. 

The next day, the physical education teacher said that he was missing an assistant in organizing the basketball team training, and asked the student if he was interested. The student reluctantly nodded in agreement. Since then after school, the student went to the playground to help the teacher, and when the teacher taught the basketball players, he secretly followed, but behaved indifferently.

The physical education teacher asked the student if he wanted to learn, again the student agreed reluctantly. After finishing the training, the teacher taught the student alone. For a period of time, the student was absent. When he showed up again, there were scars on his face and body. The physical education teacher didn’t ask anything, but just pulled the student to his side, checked the wound carefully, and then went to take the medicine box.

Under the careful guidance of the physical education teacher, the student improved his skills and was successfully selected as the school team members until graduation. In high school, the student also often came back to help and trained younger players. The story was not over here.

One day, the student came to see the physical education teacher and said that he might not be able to help out for a while because he was about to go to jail. The physical education teacher did not criticize him, but said that a person should be responsible for what he did. “No matter what the situation is, you must maintain a fighting spirit, believe in yourself, forgive yourself, and think about how you entered the school basketball team.”

This story was a true story of my respected mentor, who was far away in heaven. He told it to me when I encountered the trough of life.

He didn’t like to talk at the time because his parents were killed in a car accident, leaving him and his two younger brothers alone. He went to school with injuries because some students bullied his younger brother, and he stepped forward to protect his younger brother. Later, he went to jail because he accidentally injured one of the students while protecting his brother. However, my mentor did not bow to fate. After he was released from prison, he chose to find a job and did not enter the university because he had to support the family. 

With his continuous efforts, he became a senior executive in a multinational company. As the company went public, he realized financial freedom at the age of 32. My mentor did not forget the physical education teacher. In fact, he has been helping the family of the physical education teacher anonymously. In the last year of his life, while fighting against cancer, he was studying for a doctorate degree, and he did not forget to guide me on the problems I encountered in the entrepreneurial process. Thank you so much, my dear mentor! I really appreciate your guidance.

Many times, we always look at people with colored glasses unconsciously. In fact, we don’t know what others have experienced. Remember to treat others nicely and respectfully. Sometimes our little effort may be of great significance to others. On the other hand, there are always unsatisfactory things in life. Get used to co-exist with difficulties. When encountering problems, solve them, let go, and continue to grow!

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Welcome to the Mans International Be Your Own Boss program